Disney releases Mandalorian first season recap to refresh your memory: You are a matter of hours from starting to enjoy the second season of the Mandalorian, because the first episode will be released on the night of Friday, October 30, exclusively on Disney Plus. Due to the closeness of the release, Disney has shared a brief recap of the first season with the aim of refreshing your memory. The video, barely 99 seconds long, is the perfect recap to remember what happened during the first chapters.
Brief but effective 'recap'

In the footage you can see how Mando, played by Pedro Pascal, accepts a job that leads him to a creature that looks extremely similar to Yoda, the legendary Jedi from Star Wars. His original name is" the Child", although on the internet we all know him as Baby Yoda. The charismatic character conquered the hearts of millions of people and is already one of the most beloved and popular faces of the intergalactic saga.

While command's goal was to take Baby Yoda with those who hired him, the Mandalorian decides to take care of him and protect him from the purposes of the villains, who turn out to be an organization dependent on the Empire —or what remains of it—. Recall that the Mandalorian is set between Star Wars: The Return Of The Jedi and Star Wars: The Force Awakens. So there are still followers of the Emperor roaming the Galaxy.

Disney releases Mandalorian first season recap

Mando faces all kinds of obstacles and along the way are added characters such as Green Karga (Carl Weathers), Cara Dune (Gina Carano), IG-11 (Taika Waititi), Kuiil and Moff Gideon. The latter is, in fact, the main villain of the Mandalorian. Despite appearing in only a few scenes in the first season, he made it clear that he is willing to do anything to hunt for Command and retrieve Baby Yoda. Even in the end we could see it with the Darksaber, an iconic saber that belonged to the Mandalorians.
Ahsoka Tano in Season 2?

Disney has already promised that Gideon will have greater relevance in the new episodes, so we'll see what his strategy will be to stop the two protagonists.

And if you're expecting surprises for the second season of the Mandalorian, various reports have anticipated the appearance of Ahsoka Tano, who will reportedly be played by Rosario Dawson. In the following weeks we will finally come out of doubt.

Disney releases Mandalorian first season recap


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Scientists discover a deadly new genetic disease, called Vexas, that affects men causing fever, blood clots and inflammation

There are likely to be hundreds of men in the United States, if not more, suffering from a newly discovered genetic disease that causes symptoms such as blood clots in the veins, recurrent fevers, abnormalities in the pulmonary system and —in 40% of patients— death.

Researchers at the National Institutes of Health (NIH) discovered the disease, called VEXAS, working the other way around: instead of grouping people with similar symptoms and looking for biological explanations, they looked in the genetic makeup of 2,500 people for variations that could be related to the wide range of symptoms of their undiagnosed inflammatory conditions.

"We had many patients with undiagnosed inflammatory conditions coming to the NIH Clinical Center, and we could not diagnose them," explains Dr. David B. Beck, NHGRI Clinical Fellow and lead author of the paper, which was published Tuesday in the New England Journal of Medicine, in a statement.

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"That's when we came up with the idea of doing it the opposite way. Instead of starting with symptoms, start with a list of genes. Then, study the genomes of undiagnosed individuals and see where it takes us," he adds.

Using that method, scientists eventually identified three middle-aged men who had the same mutations in a gene called UBA1. They later discovered another 22 men with the same mutations and similar symptoms, such as blood clots and fevers.

The research team named the disease VEXAS for its key characteristics: vacuoles (unusual cavity-like structures in certain cells), enzyme E1 (which is related to UBA1), X-linked (by the chromosome to which it is connected), autoinflammatory (meaning that the immune system accidentally attacks the body) and somatic (since the disease seems to arise at some point in the patient's life, rather than at birth).

Researchers suspect that VEXAS has only been found in men because it is linked to The X chromosome, of which men have only one. The additional X chromosome of women, according to their hypothesis, could be protective in this case.

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Since the article was published, 25 more patients have been found with the syndrome, but the authors of the study expect the true prevalence to be much higher, according to NBC News, as there are almost 125 million people in the United States with some form of chronic inflammatory disease.

"This fascinating discovery is of immediate importance to rheumatologists and has far-reaching consequences of general clinical interest," Dr. Ephrat Levy-Lahad and Mary-Claire King, researchers who were not involved in the study, write in an editorial.

For scientists, the revelation that the "genome first" strategy works could help identify other previously undiscovered genetic conditions.

For health professionals, these findings will help diagnose and treat patients with inflammatory conditions, and could improve the classification system for those diseases, the researchers hope.

For patients who have been battling mysterious symptoms and seeking effective treatments without success, the discovery also changes things.

"This opens up a whole world of therapeutic potentials in the future," Dr. Natalie Azar, assistant clinical professor of Medicine and rheumatology at NYU Langone, tells NBC.


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