Scientist developed AstraZeneca vaccine triplets mother and her children have participated in the trial: The pharmaceutical company AstraZeneca has just announced that the company's coronavirus vaccine, developed in partnership with the University of Oxford, has an average efficacy of 70%, according to preliminary data from the last stages of clinical trials with more than 20, 000 volunteers in the UK and Brazil.

The results varied depending on the dose.

Nearly 9,000 volunteers received two full doses at least a month apart, a regimen that was only 62% effective. But about 2,700 volunteers received half a dose for the first, followed by a full dose for the second. Under that regime, the effectiveness of the vaccine rose to 90%.

As young adults in their 20s, Gilbert's children fit the typical profile of a vaccine trial volunteer. To participate in AstraZeneca trials, volunteers must be at least 18 years old. They must also be healthy or have a stable underlying medical condition.

Gilbert told Bloomberg in July that he was not worried about his children joining the rehearsal.

"We didn't really discuss it, as I wasn't much at home at the time," he said, adding, "We know the adverse effects profile and we know the dose to use because we've done this many times before."

Scientist developed AstraZeneca vaccine triplets mother

Gilbert is a veteran vaccine researcher. She joined the University of Oxford as a senior postdoctoral researcher in 1994. Five years later, she became a university professor, just a year after giving birth to premature triplets.

Her husband, scientist Rob Blundell, became the main caregiver of the family. Gilbert, meanwhile, excelled at Oxford, where he received funding to lead his own research group on the development of the flu vaccine in 2007.

"The nursery fees would have cost more than all my income as a postdoctoral scientist, so my partner has had to sacrifice his own career to care for our children," Gilbert writes in his university biography.

Her three children are now studying biochemistry. Gilbert's daughters, Caitlin and Susannah, attend Oxford, while their son, Freddie, goes to the University of Bath.

Since the beginning of the pandemic, Gilbert has emerged as a trusted scientific voice and as the public face of AstraZeneca's essay. She has been profiled several times this year, interviewed on television, and even named one of the BBC's 100 inspiring and influential women of 2020.

"I, for my part, trust 100% the lady who injected her own children," writes Merve Emre, an assistant professor of English at Oxford, on Twitter.

Before the new coronavirus, SARS-CoV-2, existed, Gilbert was studying a similar human coronavirus: MERS-CoV. The virus causes Middle East Respiratory Syndrome (MERS), a disease that has infected only 2,500 people worldwide, but is much more deadly than COVID-19.

Gilbert'S MERS vaccine advanced to a clinical trial phase in December 2019, just as the new coronavirus was beginning to spread in China.

Its COVID-19 vaccine now uses a similar technology: both injections are based on a chimpanzee virus called ChAdOx1 to trigger an immune response in humans.

This type of injection, known as a viral vector vaccine, is relatively easy to develop compared to traditional vaccines. Gilbert's team designed their vaccine within days of getting their hands on the SARS-CoV-2 genome. By April, Gilbert predicted that his vaccine could be available in six months.

"I have a high degree of confidence in this vaccine because it is a technology that we have used before," he told the BBC.

For a while, it seemed that AstraZeneca would reach that milestone, but the company briefly parilized its trials in September after an "unexplained illness" in a participant from the UK.

The trial in the UK resumed less than a week later, after local regulators determined it was safe to do so. In a press release, Oxford said that"no serious safety events related to the vaccine have been identified."

However, the company's trial in the United States did not receive approval from the Food and Drug Administration to resume until October. That means their results have been slightly delayed, though experts believe they could still be released this winter.

The US trial is testing two full doses of the vaccine, suggesting that the results could be less impressive than those published earlier this month by Pfizer and Moderna. Pfizer's vaccine demonstrated 95% effectiveness in preventing COVID-19, while Moderna's would have 94.5% effectiveness. But, unlike these vaccines, AstraZeneca's do not need to be stored at subzero temperatures, making it easy to distribute them around the world.

On Monday, an AstraZeneca spokesman told STAT that the company is considering adding the half-dose regimen to its ongoing clinical trials.

"This vaccine should do what we always wanted it to do," Gilbert said. "We wanted a vaccine for the world, not just for high-income countries."

Scientist developed AstraZeneca vaccine triplets mother

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The Ministry of Transport values testing with scooter companies in specific cities as a 'sandbox': this is its plan

The Congress of Deputies approved in September the financial sandbox law, which seeks to enhance the digital transformation of the sector thanks to the creation of a testing space that facilitates and monitors new innovation projects. This is an idea that the Ministry of Transport wants to transfer to its land.

This Tuesday, the director of the Technical Office of the mobility strategy of the Ministry of transport, mobility and Urban Agenda, Ánggeles Marín, has explained in an event organized by Adigital that in these tests would fit the companies of scooters, motorcycles, bicycles and shared electric cars, since the project aims to host all kinds of initiatives that improve mobility in cities.

"The idea we have is not restrictive," he replied to Business Insider Spain's questions. "The idea is: I have a new model or service [...] that for what it is collides with the current regulations. In that framework, everything we manage to create that sandbox, that is, that an administration participates, that we go hand in hand, if necessary, of a city council, so that we can create that framework", he said.

The Ministry spokeswoman has insisted that she does not want to create expectations for any specific type of companies, but has also stressed that in the case of sharing companies that the project is not closed to anything and that there is no restriction for them to enter. He also insisted that at the moment it was only a text that was being drafted for a law that had not been published.

Even so, the proposal has caused a buzz among the speakers of the talk, among which were the director-general in Iberia in the company of scooters shared Bird, Toni Riera, the vice president of Public Affairs Cabify, Mariano Silveyra; the director of Communication in Spain and Portugal of Blablacar, Itziar Garcia, the deputy director of the Studies and Reports of the CNMC, Lara Tobias, director of adigital association Policy, Marta Becerra.

Precisely the companies of shared electric scooters have been demanding a regulatory framework that allows them to operate with greater safety in cities, if possible one at the national level that does not force the user to follow different rules in each Spanish city he visits.

In that sense, expressed recently by the director general of the scooters Lime in Spain, Portugal and Latin america, Alvaro Salvat, in an interview with Business Insider Spain in calling for a regulation that includes key issues such as where to park, where you can move maximum speed, or how to make a public competition to determine what companies can operate and how many vehicles in each population.

Salvat has explained this Tuesday, in a previous presentation within the same event, that he himself has been fined for riding a scooter on the Zaragoza Road, something he did to avoid driving on the sidewalk, a prohibited area for these vehicles in Madrid; thus evidencing the confusion to which leads the user that each city applies different rules.

And in a similar way it has transmitted this Tuesday the head of bird Toni Riera, since his company is the one that is present in a greater number of Spanish cities and plans to expand to 10 others in the first quarter of 2021, year in which it promises to reach profitability and perhaps go public. What is unclear is whether these companies would fit the sandbox model the Ministry is thinking about.

"Within the promotion of innovation in transport and mobility what we are considering is the creation of a regulatory sandbox," Marín has developed.

"What is it? A sandbox, the word, comes from a sandbox where children play. It is a little box where a child can play without hurting himself. And what is a regulatory sandbox? It is a regulatory framework bounded in space and time where we can test that regulation does not allow us."

The director of the Technical Office of the Mobility Strategy has specified that it is that when a developer has an idea, whether a company or an institution, that does not fit in the current rules because that field is not regulated or because they clash with any law, but the State understands

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